Reactome | PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex

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PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex Show undefined attributes

authored	[InstanceEdit:9823562] Orlic-Milacic, Marija, 2023-01-06
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9821411] Orlic-Milacic, Marija, 2022-12-03
dbId	9821412
displayName	PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex
edited	[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
eventOf	[Pathway:R-HSA-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Homo sapiens [Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes - Homo sapiens
followingEvent	[Reaction:R-HSA-9843119] MLL4-ASCOM,(MLL3-ASCOM) complex is recruited to ligand- and coactivator-bound PPARG:RXRA heterodimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-4754224] KDM6A [nucleoplasm] [Complex:R-HSA-9676265] MLL3 complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-376414] NCOA6 [nucleoplasm] [Complex:R-HSA-9821387] PAXIP1:PAGR1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4687068] PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex [LiteratureReference:9821408] The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex [LiteratureReference:9772762] Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex
orthologousEvent	[Reaction:R-BTA-9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex - Bos taurus [Reaction:R-MMU-9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex - Mus musculus
output	[Complex:R-HSA-9821407] MLL3-ASCOM [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9821395] PAXIP1 binds PAGR1 - Homo sapiens [Reaction:R-HSA-9676254] Formation of the MLL3 complex - Homo sapiens
releaseDate	2023-03-29
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9827909] Van, Hieu, 2023-02-08 [InstanceEdit:9827910] Ge, Kai, 2023-02-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9821412
summation	[Summation:9821421] The MLL3 complex (KMT2C:WRAD, where the WRAD subcomplex cons...
updateTrackers	[UpdateTracker:9910976] Update Tracker - [Reaction:9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex - v89:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9910976] Update Tracker - [Reaction:9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex - v89:[modifyText]
(precedingEvent)	[Reaction:R-HSA-9843119] MLL4-ASCOM,(MLL3-ASCOM) complex is recruited to ligand- and coactivator-bound PPARG:RXRA heterodimer
(hasEvent)	[Pathway:R-HSA-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes [Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes