Reactome | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes

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Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Show undefined attributes

authored	[InstanceEdit:9906644] Orlic-Milacic, Marija, 2024-04-01
created	[InstanceEdit:9818560] Orlic-Milacic, Marija, 2022-10-18
dbId	9818564
displayName	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
doi	10.3180/R-HSA-9818564.2
edited	[InstanceEdit:9919285] Orlic-Milacic, Marija, 2024-08-20
eventOf	[Pathway:R-HSA-9917777] Epigenetic regulation by WDR5-containing histone modifying complexes - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9821395] PAXIP1 binds PAGR1 - Homo sapiens [Reaction:R-HSA-9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex - Homo sapiens [Reaction:R-HSA-9821410] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex - Homo sapiens [Pathway:R-HSA-9851695] Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9772559] Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes [LiteratureReference:9818191] The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers [LiteratureReference:9830575] HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis [LiteratureReference:9830580] COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer [LiteratureReference:9833344] Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors [LiteratureReference:9771324] Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase [LiteratureReference:9821223] Epigenetic balance of gene expression by Polycomb and COMPASS families [LiteratureReference:9828135] H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation [LiteratureReference:9970971] A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription
maxDepth	4
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
orthologousEvent	[Pathway:R-CEL-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Caenorhabditis elegans [Pathway:R-DME-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Drosophila melanogaster [Pathway:R-GGA-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Gallus gallus [Pathway:R-DRE-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Danio rerio [Pathway:R-SSC-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Sus scrofa [Pathway:R-BTA-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Bos taurus [Pathway:R-CFA-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Canis familiaris [Pathway:R-RNO-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Rattus norvegicus [Pathway:R-MMU-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Mus musculus
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9970975] Aberin, Marvin Angelo E, 2025-10-31 [InstanceEdit:9970977] Khag, Joy, 2025-10-31 [InstanceEdit:9970978] Wang, Shu-Ping, 2025-10-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9818564
summation	[Summation:9830403] The KMT2C (MLL3) complex, together with the related KMT2D (M...
updateTrackers	[UpdateTracker:9971873] Update Tracker - [Pathway:9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - v95:[modifyText, removeLiteratureReference]

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(updatedInstance)	[UpdateTracker:9971873] Update Tracker - [Pathway:9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - v95:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-9917777] Epigenetic regulation by WDR5-containing histone modifying complexes

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