Reactome | Formation of the MLL3 complex

Schema > Reaction > Entries

Formation of the MLL3 complex Show undefined attributes

authored	[InstanceEdit:9676291] Orlic-Milacic, Marija, 2020-02-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9676262] Orlic-Milacic, Marija, 2020-02-11
dbId	9676254
displayName	Formation of the MLL3 complex
edited	[InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
eventOf	[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes - Homo sapiens
followingEvent	[Reaction:R-HSA-9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex - Homo sapiens [Reaction:R-HSA-5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) - Homo sapiens [Reaction:R-HSA-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - Homo sapiens [Reaction:R-HSA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1183224] KMT2C [nucleoplasm] [Complex:R-HSA-9675213] WRAD complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9676266] The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases [LiteratureReference:9771695] Structural basis of nucleosome recognition and modification by MLL methyltransferases [LiteratureReference:9772254] Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Formation of the MLL3 complex
orthologousEvent	[Reaction:R-CEL-9676254] Formation of the MLL3 complex - Caenorhabditis elegans [Reaction:R-DME-9676254] Formation of the MLL3 complex - Drosophila melanogaster [Reaction:R-GGA-9676254] Formation of the MLL3 complex - Gallus gallus [Reaction:R-SSC-9676254] Formation of the MLL3 complex - Sus scrofa [Reaction:R-BTA-9676254] Formation of the MLL3 complex - Bos taurus [Reaction:R-RNO-9676254] Formation of the MLL3 complex - Rattus norvegicus [Reaction:R-MMU-9676254] Formation of the MLL3 complex - Mus musculus
output	[Complex:R-HSA-9676265] MLL3 complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9675214] Formation of the WRAD complex - Homo sapiens
releaseDate	2023-03-29
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9827909] Van, Hieu, 2023-02-08 [InstanceEdit:9827910] Ge, Kai, 2023-02-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9676254
summation	[Summation:9676256] KMT2C (also known as MLL3) binds the WRAD complex, consistin...

Referrals

(precedingEvent)

[Reaction:R-HSA-9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex
[Reaction:R-HSA-5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)
[Reaction:R-HSA-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)
[Reaction:R-HSA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)

(hasEvent)

[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes

Cite Us!