Reactome | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes

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Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101911
displayName	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
eventOf	[Pathway:R-MMU-9917777] Epigenetic regulation by WDR5-containing histone modifying complexes - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-9821395] PAXIP1 binds PAGR1 - Mus musculus [Reaction:R-MMU-9821412] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex - Mus musculus [Reaction:R-MMU-9821410] PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex - Mus musculus [Pathway:R-MMU-9851695] Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes - Mus musculus
inferredFrom	[Pathway:R-HSA-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9818564
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9917777] Epigenetic regulation by WDR5-containing histone modifying complexes
(inferredTo)	[Pathway:R-HSA-9818564] Epigenetic regulation of gene expression by MLL3 and MLL4 complexes

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