Reactome | TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]

Schema > Complex > Entries

TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:9817381] protein serine/threonine kinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189 - Homo sapiens
created	[InstanceEdit:9817410] Shamovsky, Veronica, 2022-09-17
dbId	9817409
displayName	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
goCellularComponent	[GO_CellularComponent:161217] death-inducing signaling complex
hasComponent	[CandidateSet:R-HSA-5357900] BIRC2,3,4 [cytosol] [Complex:R-HSA-9796690] CYLD:SPATA2:LUBAC [cytosol] [EntityWithAccessionedSequence:R-HSA-9793681] K63,M1polyUb-RIPK1 [cytosol] [DefinedSet:R-HSA-9730454] p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] [DefinedSet:R-HSA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-HSA-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-HSA-66370] TRAF2 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Mus musculus [Complex:R-RNO-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Rattus norvegicus [Complex:R-CFA-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Canis familiaris [Complex:R-BTA-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Bos taurus [Complex:R-SSC-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Sus scrofa [Complex:R-DRE-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Danio rerio
maxDepth	5
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE
producedByEvent	[Reaction:R-HSA-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9817409
updateTrackers	[UpdateTracker:9928590] Update Tracker - [Complex:9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - v91:[updateContainedComponent] [UpdateTracker:9905025] Update Tracker - [Complex:9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - v84:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9928590] Update Tracker - [Complex:9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - v91:[updateContainedComponent] [UpdateTracker:9905025] Update Tracker - [Complex:9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - v84:[add_removeHasComponent]
(input)	[Reaction:R-HSA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189
(output)	[Reaction:R-HSA-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex
(physicalEntity)	[CatalystActivity:9817381] protein serine/threonine kinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]

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