Reactome | TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]

Schema > Complex > Entries

TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10323597] protein serine/threonine kinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-CFA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10323596
displayName	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
hasComponent	[CandidateSet:R-CFA-5357900] BIRC2,3,4 [cytosol] [Complex:R-CFA-9796690] CYLD:SPATA2:LUBAC [cytosol] [DefinedSet:R-CFA-9730454] p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] [EntityWithAccessionedSequence:R-CFA-9793681] RIPK1 [cytosol] [DefinedSet:R-CFA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-CFA-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-CFA-66370] TRAF2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Homo sapiens
maxDepth	5
name	TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE
producedByEvent	[Reaction:R-CFA-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-9817409
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-CFA-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189
(physicalEntity)	[CatalystActivity:10323597] protein serine/threonine kinase activity of TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
(output)	[Reaction:R-CFA-9817411] TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex
(inferredTo)	[Complex:R-HSA-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]

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