Reactome | LUBAC ubiquitinates CFLAR at K351, K353

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LUBAC ubiquitinates CFLAR at K351, K353 Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10550294
displayName	LUBAC ubiquitinates CFLAR at K351, K353
eventOf	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Homo sapiens
input	[Complex:R-SSC-9794013] CFLAR:LUBAC:Ub:UBE2D3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LUBAC ubiquitinates CFLAR at K351, K353 LUBAC ubiquitinates FLIP(l) at K351,K353
output	[EntityWithAccessionedSequence:R-SSC-9794015] CASP8 [cytosol] [Complex:R-SSC-5357865] LUBAC [cytosol] [EntityWithAccessionedSequence:R-SSC-8864201] UBE2L3 [cytosol]
precedingEvent	[Reaction:R-SSC-9794008] LUBAC binds CFLAR - Sus scrofa
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-9793988
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-9793988] LUBAC ubiquitinates CFLAR at K351, K353

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