Reactome | Active IKBKB phosphorylates NF-kappa-B inhibitor

Schema > Reaction > Entries

Active IKBKB phosphorylates NF-kappa-B inhibitor Show undefined attributes

catalystActivity	[CatalystActivity:10550233] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10550235
displayName	Active IKBKB phosphorylates NF-kappa-B inhibitor
eventOf	[Pathway:R-SSC-445989] TAK1-dependent IKK and NF-kappa-B activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-168166] NF-kappa-B complex is transported from cytosol to nucleus - Sus scrofa
inferredFrom	[Reaction:R-HSA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-168130] NFkB inhibitor:NFkB complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active IKBKB phosphorylates NF-kappa-B inhibitor
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol] [DefinedSet:R-SSC-177678] Phospho-NF-kappaB Inhibitor [cytosol]
precedingEvent	[Reaction:R-SSC-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Sus scrofa
regulatedBy	[NegativeRegulation:10459402] Negative regulation by 'NKIRAS [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9773803
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-445989] TAK1-dependent IKK and NF-kappa-B activation
(precedingEvent)	[Reaction:R-SSC-168166] NF-kappa-B complex is transported from cytosol to nucleus
(inferredTo)	[Reaction:R-HSA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor

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