Reactome | Prolactin receptor ligands bind the prolactin receptor

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Prolactin receptor ligands bind the prolactin receptor Show undefined attributes

authored	[InstanceEdit:1363240] Jupe, S, 2011-06-13
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:976976] Jupe, S, 2010-10-14
dbId	976991
displayName	Prolactin receptor ligands bind the prolactin receptor
edited	[InstanceEdit:1671724] Jupe, S, 2011-10-17
eventOf	[Pathway:R-HSA-1170546] Prolactin receptor signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1671687] PRLR activation - Homo sapiens
input	[Complex:R-HSA-1364076] PRLR:JAK2 dimer [plasma membrane] [DefinedSet:R-HSA-1172021] Prolactin receptor ligands [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1172026] Crystal structure and site 1 binding energetics of human placental lactogen
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Prolactin receptor ligands bind the prolactin receptor
orthologousEvent	[Reaction:R-GGA-976991] Prolactin receptor ligands bind the prolactin receptor - Gallus gallus [Reaction:R-XTR-976991] Prolactin receptor ligands bind the prolactin receptor - Xenopus tropicalis [Reaction:R-DRE-976991] Prolactin receptor ligands bind the prolactin receptor - Danio rerio [Reaction:R-SSC-976991] Prolactin receptor ligands bind the prolactin receptor - Sus scrofa [Reaction:R-BTA-976991] Prolactin receptor ligands bind the prolactin receptor - Bos taurus [Reaction:R-CFA-976991] Prolactin receptor ligands bind the prolactin receptor - Canis familiaris [Reaction:R-RNO-976991] Prolactin receptor ligands bind the prolactin receptor - Rattus norvegicus [Reaction:R-MMU-976991] Prolactin receptor ligands bind the prolactin receptor - Mus musculus
output	[Complex:R-HSA-1671652] PRLR ligands:PRLR:JAK2 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-1364044] PRLR:JAK2 dimerizes - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1370510] Negative regulation by 'PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]'
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1977929] Goffin, V, 2011-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-976991
summation	[Summation:976966] Human PRLR binds at least 3 related peptide ligands namely p...

Referrals

(hasEvent)	[Pathway:R-HSA-1170546] Prolactin receptor signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-1671687] PRLR activation

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