Reactome | PRLR activation

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PRLR activation Show undefined attributes

authored	[InstanceEdit:1363240] Jupe, S, 2011-06-13
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1671654] Jupe, S, 2011-10-17
dbId	1671687
displayName	PRLR activation
edited	[InstanceEdit:1671724] Jupe, S, 2011-10-17
eventOf	[Pathway:R-HSA-1170546] Prolactin receptor signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1370505] PRLR is phosphorylated at Ser-349 - Homo sapiens [Reaction:R-HSA-1675473] SH2B binds JAK2 - Homo sapiens [BlackBoxEvent:R-HSA-982810] JAK2 phosphorylation - Homo sapiens
input	[Complex:R-HSA-1671652] PRLR ligands:PRLR:JAK2 dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1671707] Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PRLR activation
orthologousEvent	[BlackBoxEvent:R-GGA-1671687] PRLR activation - Gallus gallus [BlackBoxEvent:R-XTR-1671687] PRLR activation - Xenopus tropicalis [BlackBoxEvent:R-DRE-1671687] PRLR activation - Danio rerio [BlackBoxEvent:R-SSC-1671687] PRLR activation - Sus scrofa [BlackBoxEvent:R-BTA-1671687] PRLR activation - Bos taurus [BlackBoxEvent:R-CFA-1671687] PRLR activation - Canis familiaris [BlackBoxEvent:R-RNO-1671687] PRLR activation - Rattus norvegicus [BlackBoxEvent:R-MMU-1671687] PRLR activation - Mus musculus
output	[Complex:R-HSA-976956] PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-976991] Prolactin receptor ligands bind the prolactin receptor - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1977929] Goffin, V, 2011-11-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1671687
summation	[Summation:1671702] Ligand binding activates the PRLR, probably by causing a sub...

Referrals

(hasEvent)	[Pathway:R-HSA-1170546] Prolactin receptor signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-1370505] PRLR is phosphorylated at Ser-349 [Reaction:R-HSA-1675473] SH2B binds JAK2 [BlackBoxEvent:R-HSA-982810] JAK2 phosphorylation