Reactome | Prolactin receptor ligands bind the prolactin receptor

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Prolactin receptor ligands bind the prolactin receptor Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10590948
displayName	Prolactin receptor ligands bind the prolactin receptor
eventOf	[Pathway:R-DRE-1170546] Prolactin receptor signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DRE-1671687] PRLR activation - Danio rerio
inferredFrom	[Reaction:R-HSA-976991] Prolactin receptor ligands bind the prolactin receptor - Homo sapiens
input	[Complex:R-DRE-1364076] PRLR:JAK2 dimer [plasma membrane] [DefinedSet:R-DRE-1172021] Prolactin receptor ligands [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Prolactin receptor ligands bind the prolactin receptor
output	[Complex:R-DRE-1671652] PRLR ligands:PRLR:JAK2 dimer [plasma membrane]
precedingEvent	[Reaction:R-DRE-1364044] PRLR:JAK2 dimerizes - Danio rerio
regulatedBy	[NegativeRegulation:10590949] Negative regulation by 'PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-976991
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1170546] Prolactin receptor signaling
(precedingEvent)	[BlackBoxEvent:R-DRE-1671687] PRLR activation
(inferredTo)	[Reaction:R-HSA-976991] Prolactin receptor ligands bind the prolactin receptor

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