Prolactin receptor ligands bind the prolactin receptor

Stable Identifier
R-HSA-976991
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Prolactin receptor ligands bind the prolactin receptor
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Human PRLR binds at least 3 related peptide ligands namely prolactin, placental lactogen (PL) and growth hormone (GH). In non primates, GH is not able to bind the PRLR. Human GH binding to the PRLR is zinc-dependent (Cunningham et al. 1990). All three ligands bind the extracellular domain and have apparently identical actions. Two disulfide-linked cysteines in the D1 subdomain are involved in ligand binding while the WSXWS motif in the D2 subdomain is probably required for folding and cellular trafficking.
Literature References
PubMed ID Title Journal Year
16546209 Crystal structure and site 1 binding energetics of human placental lactogen

Walsh, ST, Kossiakoff, AA

J Mol Biol 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
Orthologous Events
Prolactin receptor ligands bind the prolactin receptor (Canis familiaris)
Prolactin receptor ligands bind the prolactin receptor (Gallus gallus)
Prolactin receptor ligands bind the prolactin receptor (Mus musculus)
Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)
Prolactin receptor ligands bind the prolactin receptor (Sus scrofa)
Prolactin receptor ligands bind the prolactin receptor (Xenopus tropicalis)
Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2010-10-14)
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