Reactome | tissue factor (TF) + factor VII (F7) -> TF:F7 complex

Schema > Reaction > Entries

tissue factor (TF) + factor VII (F7) -> TF:F7 complex Show undefined attributes

authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
dbId	140783
displayName	tissue factor (TF) + factor VII (F7) -> TF:F7 complex
eventOf	[Pathway:R-HSA-9769735] Initiation of coagulation cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-9822513] TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst) - Homo sapiens
input	[Complex:R-HSA-8959612] Factor VII:Ca2+ [extracellular region] [EntityWithAccessionedSequence:R-HSA-140704] PalmC, 2HC-F3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140779] Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine [LiteratureReference:9671743] Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	tissue factor (TF) + factor VII (F7) -> TF:F7 complex formation of TF:F7 complex
orthologousEvent	[Reaction:R-GGA-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Gallus gallus [Reaction:R-XTR-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Xenopus tropicalis [Reaction:R-DRE-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Danio rerio [Reaction:R-SSC-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Sus scrofa [Reaction:R-BTA-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Bos taurus [Reaction:R-CFA-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Canis familiaris [Reaction:R-RNO-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Rattus norvegicus [Reaction:R-MMU-140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - Mus musculus
output	[Complex:R-HSA-140775] TF:F7 [plasma membrane]
precedingEvent	[Reaction:R-HSA-140761] sequestered tissue factor -> tissue factor - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-158643] Positive regulation by 'Ca2+ [extracellular region]'
regulationReference	[RegulationReference:9671760] Positive regulation by 'Ca2+ [extracellular region]' Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-140783
summation	[Summation:140784] This Reactome event describes binding of the cell surface-bo...
updateTrackers	[UpdateTracker:9781780] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v60:[add_removeInput] [UpdateTracker:9777119] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v72:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9939622] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v92:[modifyText] [UpdateTracker:9919444] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v90:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781780] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v60:[add_removeInput] [UpdateTracker:9777119] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v72:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9939622] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v92:[modifyText] [UpdateTracker:9919444] Update Tracker - [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex - v90:[modifyText]
(hasEvent)	[Pathway:R-HSA-9769735] Initiation of coagulation cascade
(precedingEvent)	[Reaction:R-HSA-9822513] TF:FVII+FX -> TF:FVII:FXa + FX activation peptide (TF:F7 catalyst)

Cite Us!