Reactome | miR-10b binds CDH1 mRNA

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miR-10b binds CDH1 mRNA Show undefined attributes

authored	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
dbId	9768643
displayName	miR-10b binds CDH1 mRNA
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9764562] Regulation of CDH1 mRNA translation by microRNAs - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9768618] miR-10b inhibits CDH1 mRNA translation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9793365] CDH1 mRNA [cytosol] [CandidateSet:R-HSA-9816182] miR-10b-5p RISC [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9768622] MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin [LiteratureReference:9768707] MicroRNA-10b mediates TGF-?1-regulated glioblastoma proliferation, migration and epithelial-mesenchymal transition
maxDepth	1
modified	[InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
name	miR-10b binds CDH1 mRNA
negativePrecedingEvent	[NegativePrecedingEvent:9954078] Negative relationship: CTBP1,CTBP2 represses CDH1 gene transcription [NegativePrecedingEvent:9954110] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription [NegativePrecedingEvent:9954089] Negative relationship: PKM and TGIF2 repress CDH1 gene transcription [NegativePrecedingEvent:9954101] Negative relationship: PRC2 (EZH2) mediates repression of CDH1 gene transcription [NegativePrecedingEvent:9954105] Negative relationship: SNAI1 represses CDH1 transcription [NegativePrecedingEvent:9954061] Negative relationship: SNAI2 represses CDH1 gene transcription [NegativePrecedingEvent:9954102] Negative relationship: TCF12 represses CDH1 gene transcription [NegativePrecedingEvent:9954073] Negative relationship: TCF3 represses CDH1 gene transcription [NegativePrecedingEvent:9954054] Negative relationship: TWIST1 represses CDH1 gene transcription [NegativePrecedingEvent:9954067] Negative relationship: TWIST2 represses CDH1 gene transcription [NegativePrecedingEvent:9954082] Negative relationship: WT1 represses CDH1 gene transcription [NegativePrecedingEvent:9954084] Negative relationship: ZBTB33 represses CDH1 gene transcription [NegativePrecedingEvent:9954111] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954060] Negative relationship: ZEB2 represses CDH1 gene transcription [NegativePrecedingEvent:9954094] Negative relationship: ZNF217 represses CDH1 gene transcription
output	[Complex:R-HSA-9816191] miR-10b-5p RISC:CDH1 mRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9766286] ARID1A and SWI/SNF complex stimulate CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9765372] FOXA2 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9765539] FOXJ2 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9768079] FOXQ1 represses CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9765330] KLF4 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9764863] KLF9 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9768293] RB1 and TFAP2A stimulate CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9764800] SP1 stimulates CDH1 gene transcription - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9768643
summation	[Summation:9816199] A single miR-10b target site was computationally predicted i...

Referrals

(hasEvent)	[Pathway:R-HSA-9764562] Regulation of CDH1 mRNA translation by microRNAs
(precedingEvent)	[BlackBoxEvent:R-HSA-9768618] miR-10b inhibits CDH1 mRNA translation

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