Reactome | miR-10b inhibits CDH1 mRNA translation

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miR-10b inhibits CDH1 mRNA translation Show undefined attributes

authored	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
dbId	9768618
displayName	miR-10b inhibits CDH1 mRNA translation
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9764562] Regulation of CDH1 mRNA translation by microRNAs - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9793365] CDH1 mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9768622] MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin [LiteratureReference:9768707] MicroRNA-10b mediates TGF-?1-regulated glioblastoma proliferation, migration and epithelial-mesenchymal transition
maxDepth	1
modified	[InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
name	miR-10b inhibits CDH1 mRNA translation
negativePrecedingEvent	[NegativePrecedingEvent:9954093] Negative relationship: CTBP1,CTBP2 represses CDH1 gene transcription [NegativePrecedingEvent:9954079] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription [NegativePrecedingEvent:9954072] Negative relationship: PKM and TGIF2 repress CDH1 gene transcription [NegativePrecedingEvent:9954056] Negative relationship: PRC2 (EZH2) mediates repression of CDH1 gene transcription [NegativePrecedingEvent:9954083] Negative relationship: SNAI1 represses CDH1 transcription [NegativePrecedingEvent:9954055] Negative relationship: SNAI2 represses CDH1 gene transcription [NegativePrecedingEvent:9954117] Negative relationship: TCF12 represses CDH1 gene transcription [NegativePrecedingEvent:9954095] Negative relationship: TCF3 represses CDH1 gene transcription [NegativePrecedingEvent:9954106] Negative relationship: TWIST1 represses CDH1 gene transcription [NegativePrecedingEvent:9954066] Negative relationship: TWIST2 represses CDH1 gene transcription [NegativePrecedingEvent:9954051] Negative relationship: WT1 represses CDH1 gene transcription [NegativePrecedingEvent:9954099] Negative relationship: ZBTB33 represses CDH1 gene transcription [NegativePrecedingEvent:9954071] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954104] Negative relationship: ZEB2 represses CDH1 gene transcription [NegativePrecedingEvent:9954081] Negative relationship: ZNF217 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:R-HSA-9816039] CDH1(1-882) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9768643] miR-10b binds CDH1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9766286] ARID1A and SWI/SNF complex stimulate CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9765372] FOXA2 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9765539] FOXJ2 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9768079] FOXQ1 represses CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9765330] KLF4 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9764863] KLF9 stimulates CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9768293] RB1 and TFAP2A stimulate CDH1 gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9764800] SP1 stimulates CDH1 gene transcription - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9816190] Negative gene expression regulation by 'miR-10b-5p RISC:CDH1 mRNA [cytosol]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9768618
summation	[Summation:9816202] Direct downregulation of CDH1 by microRNA miR-10b was demons...

Referrals

(hasEvent)	[Pathway:R-HSA-9764562] Regulation of CDH1 mRNA translation by microRNAs
(precedingEvent)	[NegativePrecedingEvent:9954107] Negative relationship: miR-10b inhibits CDH1 mRNA translation

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