Reactome | DsbA catalyzes disulfide crosslink formation on STa

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DsbA catalyzes disulfide crosslink formation on STa Show undefined attributes

authored	[InstanceEdit:9760533] Stephan, Ralf, 2021-12-19
catalystActivity	[CatalystActivity:9760555] protein disulfide isomerase activity of DsbA [periplasmic space]
category	transition
compartment	[Compartment:1222638] periplasmic space
created	[InstanceEdit:9760562] Stephan, Ralf, 2021-12-19
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9760559
disease	[Disease:3134792] bacterial infectious disease
displayName	DsbA catalyzes disulfide crosslink formation on STa
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9760173] Secretion of toxins - Homo sapiens
followingEvent	[Reaction:R-HSA-9760573] TolC complex exports STa - Homo sapiens
input	[DefinedSet:R-ECO-9760528] STa-SH [periplasmic space]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9760529] Extracellular secretion of Escherichia coli heat-stable enterotoxin I across the outer membrane [LiteratureReference:9760544] Mode of disulfide bond formation of a heat-stable enterotoxin (STh) produced by a human strain of enterotoxigenic Escherichia coli [LiteratureReference:9760563] Maturation pathway of Escherichia coli heat-stable enterotoxin I: requirement of DsbA for disulfide bond formation [LiteratureReference:9761010] Extracellular DsbA-insensitive folding of Escherichia coli heat-stable enterotoxin STa in vitro
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	DsbA catalyzes disulfide crosslink formation on STa
output	[DefinedSet:R-ECO-9760561] STa [periplasmic space]
precedingEvent	[Reaction:R-HSA-9760521] Unknown peptidase cleaves pro-STa - Homo sapiens
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9760559
summation	[Summation:9761009] Heat-stable enterotoxins (STa) in their active form contain ...

Referrals

(hasEvent)	[Pathway:R-HSA-9760173] Secretion of toxins
(precedingEvent)	[Reaction:R-HSA-9760573] TolC complex exports STa

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