Reactome | TolC complex exports STa

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TolC complex exports STa Show undefined attributes

authored	[InstanceEdit:9760562] Stephan, Ralf, 2021-12-19
catalystActivity	[CatalystActivity:9911478] porin activity of Tripartite (TolC) efflux pumps [cell outer membrane]
category	transition
compartment	[Compartment:20798] cell outer membrane [Compartment:984] extracellular region [Compartment:1222638] periplasmic space
created	[InstanceEdit:9760572] Stephan, Ralf, 2021-12-19
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9760573
disease	[Disease:3134792] bacterial infectious disease
displayName	TolC complex exports STa
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9760173] Secretion of toxins - Homo sapiens
input	[DefinedSet:R-ECO-9760561] STa [periplasmic space]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9760177] Molecular Determinants of Enterotoxigenic Escherichia coli Heat-Stable Toxin Secretion and Delivery [LiteratureReference:9760581] Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	TolC complex exports STa
output	[DefinedSet:R-ECO-9760577] STa [extracellular region]
precedingEvent	[Reaction:R-HSA-9760559] DsbA catalyzes disulfide crosslink formation on STa - Homo sapiens
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9760573
summation	[Summation:9761008] Escherichia coli heat-stable enterotoxins (STa) are secreted...

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[Pathway:R-HSA-9760173] Secretion of toxins

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