Reactome | NFE2L2-dependent SRXN1 gene expression

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NFE2L2-dependent SRXN1 gene expression Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9759360] Rothfels, Karen, 2021-12-02
dbId	9759358
displayName	NFE2L2-dependent SRXN1 gene expression
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes - Homo sapiens
followingEvent	[Reaction:R-HSA-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9759328] SRXN1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9759290] Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins [LiteratureReference:9759268] Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds [LiteratureReference:9759273] Beneficial role of Nrf2 in regulating NADPH generation and consumption [LiteratureReference:9759274] Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9759294] Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFE2L2-dependent SRXN1 gene expression
output	[EntityWithAccessionedSequence:R-HSA-9759366] SRXN1 [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9759334] NFE2L2 binds the SRXN1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9759361] Positive gene expression regulation by 'SRXN1 gene:p-NFE2L2 [nucleoplasm]'
regulationReference	[RegulationReference:9759365] Positive gene expression regulation by 'SRXN1 gene:p-NFE2L2 [nucleoplasm]' Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9759358
summation	[Summation:9759317] The SRXN1 gene encodes sulfiredoxin 1, which contributes to ...

Referrals

(hasEvent)	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes
(precedingEvent)	[Reaction:R-HSA-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer