NFE2L2-dependent SRXN1 gene expression

Stable Identifier
R-HSA-9759358
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NFE2L2-dependent SRXN1 gene expression
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The SRXN1 gene encodes sulfiredoxin 1, which contributes to the oxidative stress response by reducing cysteine-sulfinic bonds within PRDX1 after exposure to oxidants (Chang et al, 2004; Woo et al, 2005). SRXN1 gene expression is regulated in part by the KEAP1-NFE2L2 pathway; NFE2L2 binds to the SRXN1 promoter as assessed by ChIP to upregulate mRNA and protein levels in response to oxidative challenges (Macleod et al, 2009; Wu et al, 2011; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
20460467 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Shyr, C, Srivastava, S, Wakabayashi, N, Wasserman, WW, Singh, A, Malhotra, D, Biswal, S, Happel, C, Portales-Casamar, E, Kensler, TW, Arenillas, D

Nucleic Acids Res 2010
15590625 Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins

Yang, JS, Woo, HA, Park, SJ, Chang, TS, Jeong, W, Park, KJ, Rhee, SG

J Biol Chem 2005
21775727 Beneficial role of Nrf2 in regulating NADPH generation and consumption

Klaassen, CD, Wu, KC, Cui, JY

Toxicol Sci 2011
15448164 Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine

Woo, HA, Lee, SM, Chang, TS, Jeong, W, Park, S, Rhee, SG

J Biol Chem 2004
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
19608619 Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

MacLeod, AK, Penning, TM, Plummer, SM, Igarashi, K, Hayes, JD, McMahon, M, Higgins, LG

Carcinogenesis 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SRXN1 gene:p-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-02)
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