Reactome | SRXN1 reduces hyperoxidized PRDX1 dimer

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SRXN1 reduces hyperoxidized PRDX1 dimer Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity	[CatalystActivity:9760092] sulfiredoxin activity of SRXN1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9760093] Rothfels, Karen, 2021-12-14
dbId	9760094
displayName	SRXN1 reduces hyperoxidized PRDX1 dimer
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5631882] HOOS-C52-PRDX1 dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9759294] Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine [LiteratureReference:9759290] Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SRXN1 reduces hyperoxidized PRDX1 dimer
negativePrecedingEvent	[NegativePrecedingEvent:9767153] Futile Cycle: PRDX1 overoxidizes
orthologousEvent	[Reaction:R-SCE-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Saccharomyces cerevisiae [Reaction:R-SPO-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Schizosaccharomyces pombe [Reaction:R-DME-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Drosophila melanogaster [Reaction:R-GGA-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Gallus gallus [Reaction:R-DRE-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Danio rerio [Reaction:R-SSC-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Sus scrofa [Reaction:R-BTA-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Bos taurus [Reaction:R-CFA-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Canis familiaris [Reaction:R-RNO-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Rattus norvegicus [Reaction:R-MMU-9760094] SRXN1 reduces hyperoxidized PRDX1 dimer - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-HSA-3341319] PRDX1 dimer [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9759358] NFE2L2-dependent SRXN1 gene expression - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9760094
summation	[Summation:9760055] SRXN1 is a sulfiredoxin protein that reduces hyperoxidized m...

Referrals

(hasEvent)	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes
(precedingEvent)	[NegativePrecedingEvent:9767156] Futile Cycle: SRXN1 reduces hyperoxidized PRDX1 dimer