Reactome | HSD11B2 dehydrogenates PREDL to PREDN

HSD11B2 dehydrogenates PREDL to PREDN

Stable Identifier

R-HSA-9759259

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Prednisolone (PREDL) is dehydrogenated to prednisone (PREDN) by HSD11B2 (Diederich et al, 2002). The conversion of 11β-hydroxysteroids to 11-oxosteroids and vice versa is catalyzed by the enzymes 11β-hydroxysteroid dehydrogenase 1 and 2 (HSD11B1, HSD11B2). Although the activity of both enzymes is bidirectional in vitro, in vivo HSD11B1 acts as 11-oxosteroid reductase and HSD11B2 acts as 11β-hydroxysteroid dehydrogenase (Jamieson et al, 1995). HSD11B1 is ubiquitously expressed, with maximum activity in the liver, while HSD11B2 is mainly active in placenta, colon, and kidney cells (Ricketts et al, 1998).

Literature References

PubMed ID	Title	Journal	Year
12466373	11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids Seidelmann, D, Rochel, M, Oelkers, W, Quinkler, M, Esperling, P, Bumke-Vogt, C, Bähr, V, Burkhardt, P, Diederich, S, Eigendorff, E	J Clin Endocrinol Metab	2002
9543163	Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues Stewart, PM, Verhaeg, JM, Howie, AJ, Bujalska, I, Rainey, WE, Ricketts, ML	J Clin Endocrinol Metab	1998
7588203	11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations Edwards, CR, Jamieson, PM, Chapman, KE, Seckl, JR	Endocrinology	1995