MyD88 forms a complex with the activated TLR receptor

Stable Identifier
R-HSA-975866
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MyD88 forms a complex with the activated TLR receptor
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MyD88 is the downstream adaptor which is utilized by all TLRs, except TLR3. MyD88 comprises an N-terminal Death Domain (DD) and a C-terminal TIR. Upon ligand binding to the IL-1R or a TLR, MyD88 is rapidly recruited to the activated receptor via homotypic interactions of TIR domain, whereas the DD module recruits serine/threonine kinases such as interleukin-1-receptor-associated kinases (IRAKs).

Literature References
PubMed ID Title Journal Year
12447442 The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Horng, T, Barton, GM, Flavell, RA, Medzhitov, R

Nature 2002
9430229 MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

Wesche, H, Henzel, WJ, Shillinglaw, W, Li, S, Cao, Z

Immunity 1997
Participants
Input
Output
Participant Of
hasEvent
Authored
Shamovsky, V  (2010-10-06)
Reviewed
Gillespie, ME  (2011-02-10)
Li, L  (2011-08-04)
Created
Shamovsky, V  (2010-10-06)
Cite Us!