MyD88 forms a complex with the activated TLR receptor

Stable Identifier
R-HSA-975866
Type
Reaction
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
cytosol, plasma membrane
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MyD88 forms a complex with the activated TLR receptor
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MyD88 is the downstream adaptor which is utilized by all TLRs, except TLR3. MyD88 comprises an N-terminal Death Domain (DD) and a C-terminal TIR. Upon ligand binding to the IL-1R or a TLR, MyD88 is rapidly recruited to the activated receptor via homotypic interactions of TIR domain, whereas the DD module recruits serine/threonine kinases such as interleukin-1-receptor-associated kinases (IRAKs).

Literature References
PubMed ID Title Journal Year
9430229 MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

Henzel, WJ, Wesche, H, Li, S, Cao, Z, Shillinglaw, W

Immunity 1997
12447442 The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Barton, GM, Horng, T, Medzhitov, R, Flavell, RA

Nature 2002
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Authored
Shamovsky, V  (2010-10-06)
Reviewed
Li, L  (2011-08-04)
Gillespie, ME  (2011-02-10)
Created
Shamovsky, V  (2010-10-06)
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