MyD88 is the downstream adaptor which is utilized by all TLRs, except TLR3. MyD88 comprises an N-terminal Death Domain (DD) and a C-terminal TIR. Upon ligand binding to the IL-1R or a TLR, MyD88 is rapidly recruited to the activated receptor via homotypic interactions of TIR domain, whereas the DD module recruits serine/threonine kinases such as interleukin-1-receptor-associated kinases (IRAKs).
Henzel, WJ, Wesche, H, Li, S, Cao, Z, Shillinglaw, W
Barton, GM, Horng, T, Medzhitov, R, Flavell, RA
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