Reactome | IRAK4 autophosphorylation within the complex activated TLR:MyD88

Schema > Reaction > Entries

IRAK4 autophosphorylation within the complex activated TLR:MyD88 Show undefined attributes

authored	[InstanceEdit:975890] Shamovsky, V, 2010-10-06
catalystActivity	[CatalystActivity:975855] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643358] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] IRAK-4: a novel member of the IRAK family with the properties of an
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:975863] Shamovsky, V, 2010-10-06
dbId	975865
displayName	IRAK4 autophosphorylation within the complex activated TLR:MyD88
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-975852] IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-975876] IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:446630] Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop [LiteratureReference:937035] Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK4 autophosphorylation within the complex activated TLR:MyD88
orthologousEvent	[Reaction:R-GGA-977250] Autophosphorylation of IRAK4 bound to activated TLR5 or 15 - Gallus gallus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-975870] p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane]
precedingEvent	[Reaction:R-HSA-975873] IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor - Homo sapiens
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1186998] Gillespie, ME, 2011-02-10 [InstanceEdit:1474057] Li, L, 2011-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975865
summation	[Summation:446631] IRAK4 is activated by autophosphorylation at 3 positions wit...

Referrals

(hasEvent)	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-HSA-975852] IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex

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