IRAK4 autophosphorylation within the complex activated TLR:MyD88

Stable Identifier
R-HSA-975865
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
Locations in the PathwayBrowser
General
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IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346.

Literature References
PubMed ID Title Journal Year
17141195 Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

Cheng, H, Addona, T, Keshishian, H, Dahlstrand, E, Lu, C, Dorsch, M, Li, Z, Wang, A, Ocain, TD, Li, P, Parsons, TF, Jaffee, B, Xu, Y

Biochem Biophys Res Commun 2007
17485511 Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

Kawagoe, T, Sato, S, Jung, A, Yamamoto, M, Matsui, K, Kato, H, Uematsu, S, Takeuchi, O, Akira, S

J Exp Med 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created