Reactome | Autophosphorylation of IRAK4 bound to activated TLR5 or 15

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Autophosphorylation of IRAK4 bound to activated TLR5 or 15 Show undefined attributes

authored	[InstanceEdit:1094913] Shamovsky, V, 2010-11-30
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:977249] Shamovsky, V, 2010-10-15
dbId	977250
displayName	Autophosphorylation of IRAK4 bound to activated TLR5 or 15
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
eventOf	[Pathway:R-GGA-977240] MyD88 cascade initiated on plasma membrane - Gallus gallus
followingEvent	[Reaction:R-GGA-977237] IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex - Gallus gallus
inferredFrom	[Reaction:R-HSA-975865] IRAK4 autophosphorylation within the complex activated TLR:MyD88 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-433838] IRAK4 : MyD88 : activated TLR5 or TLR15 [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of IRAK4 bound to activated TLR5 or 15
output	[Complex:R-GGA-977234] activated TLR : MyD88 : p-IRAK4 [plasma membrane] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-GGA-434130] IRAK4 binds to activated TLR5 or 15 - Gallus gallus
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-977250
summation	[Summation:570886] Chicken IRAK4 shows 66% amino acid identity to human IRAK4. ...

Referrals

(hasEvent)	[Pathway:R-GGA-977240] MyD88 cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-GGA-977237] IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex
(inferredTo)	[Reaction:R-HSA-975865] IRAK4 autophosphorylation within the complex activated TLR:MyD88

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