Reactome | SLC29A1,2 transport 6MP from extracellular region to cytosol

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SLC29A1,2 transport 6MP from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:9751031] Jassal, Bijay, 2021-08-17
catalystActivity	[CatalystActivity:9751014] nucleoside transmembrane transporter activity of SLC29A1,2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9751031] Jassal, Bijay, 2021-08-17
dbId	9751024
displayName	SLC29A1,2 transport 6MP from extracellular region to cytosol
edited	[InstanceEdit:9751031] Jassal, Bijay, 2021-08-17
eventOf	[Pathway:R-HSA-9748787] Azathioprine ADME - Homo sapiens
followingEvent	[Reaction:R-HSA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22548] xenobiotic transmembrane transport
input	[ChemicalDrug:R-ALL-9751015] 6MP [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9751018] Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines [LiteratureReference:9751017] The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells [LiteratureReference:9750586] Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC29A1,2 transport 6MP from extracellular region to cytosol
orthologousEvent	[Reaction:R-PFA-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Plasmodium falciparum [Reaction:R-SCE-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Saccharomyces cerevisiae [Reaction:R-DDI-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Dictyostelium discoideum [Reaction:R-CEL-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Mus musculus
output	[ChemicalDrug:R-ALL-9748998] 6MP [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9751051] GSH cleaves AZA to 6MP - Homo sapiens
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9756856] Huddart, Rachel, 2021-10-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9751024
summation	[Summation:9751048] Candidates for the transport of thiopurines like 6-mercaptop...

Referrals

(hasEvent)	[Pathway:R-HSA-9748787] Azathioprine ADME
(precedingEvent)	[Reaction:R-HSA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP

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