SLC29A1,2 transport 6MP from extracellular region to cytosol

Stable Identifier
R-HSA-9751024
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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SLC29A1,2 transport 6MP from extracellular region to cytosol
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Candidates for the transport of thiopurines like 6-mercaptopurine (6MP) into the cell include the transporters SLC29A1 (equilibrative nucleoside transporter 1, ENT1) and SLC29A2 (equilibrative nucleoside transporter 2, ENT2). Down-regulation of these influx transporters may play a major role in 6MP resistance of cells (Fotoohi et al. 2006, Peng et al. 2008, Karim et al. 2011).
Literature References
PubMed ID Title Journal Year
17996297 Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine

Fu, L, Damaraju, VL, Chen, ZS, Shi, Z, Cass, CE, Wu, HC, Peng, XX, Zhou, Y, Tiwari, A, Kruh, GD, Huang, XC

Leuk Res 2008
16530731 Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines

Peterson, C, Fotoohi, AK, Albertioni, F, Lindqvist, M

Biochem Biophys Res Commun 2006
21723252 The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells

Moshfegh, A, Hashemi, J, Larsson, C, Karim, H, Albertioni, F, Fotoohi, AK

Biochem Biophys Res Commun 2011
Participants
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Output
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as an event of
Event Information
Go Biological Process
xenobiotic transmembrane transport (0006855)
Catalyst Activity

nucleoside transmembrane transporter activity of SLC29A1,2 [plasma membrane]

Physical Entity
SLC29A1,2 [plasma membrane] (Homo sapiens)
Activity
nucleoside transmembrane transporter activity (GO:0005337)
Orthologous Events
SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Caenorhabditis elegans)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Dictyostelium discoideum)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Rattus norvegicus)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)
SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)
Authored
Jassal, B  (2021-08-17)
Reviewed
Huddart, R  (2021-10-19)
Created
Jassal, B  (2021-08-17)
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