Reactome | SLC29A1,2 transport 6MP from extracellular region to cytosol

SLC29A1,2 transport 6MP from extracellular region to cytosol

Stable Identifier

R-HSA-9751024

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SLC29A1,2 transport 6MP from extracellular region to cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Candidates for the transport of thiopurines like 6-mercaptopurine (6MP) into the cell include the transporters SLC29A1 (equilibrative nucleoside transporter 1, ENT1) and SLC29A2 (equilibrative nucleoside transporter 2, ENT2). Down-regulation of these influx transporters may play a major role in 6MP resistance of cells (Fotoohi et al. 2006, Peng et al. 2008, Karim et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
17996297	Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine Peng, XX, Shi, Z, Damaraju, VL, Huang, XC, Kruh, GD, Wu, HC, Zhou, Y, Tiwari, A, Fu, L, Cass, CE, Chen, ZS	Leuk Res	2008
16530731	Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines Fotoohi, AK, Lindqvist, M, Peterson, C, Albertioni, F	Biochem Biophys Res Commun	2006
21723252	The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells Karim, H, Hashemi, J, Larsson, C, Moshfegh, A, Fotoohi, AK, Albertioni, F	Biochem Biophys Res Commun	2011