Reactome | TPMT transfers methyl group to 6MP, forming 6MeMP

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TPMT transfers methyl group to 6MP, forming 6MeMP Show undefined attributes

authored	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
catalystActivity	[CatalystActivity:158629] thiopurine S-methyltransferase activity of TPMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
dbId	9748983
displayName	TPMT transfers methyl group to 6MP, forming 6MeMP
edited	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
eventOf	[Pathway:R-HSA-9748787] Azathioprine ADME - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
input	[ChemicalDrug:R-ALL-9748998] 6MP [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9750256] Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TPMT transfers methyl group to 6MP, forming 6MeMP 6MP--TPMT-->6MeMP
orthologousEvent	[Reaction:R-GGA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Gallus gallus [Reaction:R-XTR-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Xenopus tropicalis [Reaction:R-DRE-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Danio rerio [Reaction:R-SSC-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Sus scrofa [Reaction:R-BTA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Bos taurus [Reaction:R-CFA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Canis familiaris [Reaction:R-RNO-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Rattus norvegicus [Reaction:R-MMU-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Mus musculus
output	[SimpleEntity:R-ALL-9748982] 6MeMP [cytosol] [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-9748996] GST dimers cleave AZA to 6MP - Homo sapiens [Reaction:R-HSA-9751037] SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Homo sapiens
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9756856] Huddart, Rachel, 2021-10-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9748983
summation	[Summation:9750183] 6-mercaptopurine (6MP) can be metabolized via three competin...

Referrals

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[Pathway:R-HSA-9748787] Azathioprine ADME

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