Reactome | Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

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Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10025211
displayName	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
eventOf	[Pathway:R-MMU-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-975103] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation - Mus musculus
inferredFrom	[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
input	3 × [Polymer:R-MMU-450152] K63polyUb [cytosol] [Complex:R-MMU-975164] p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] 3 × [Complex:R-MMU-446878] TAK1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
output	[Complex:R-MMU-975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]
precedingEvent	[Polymerisation:R-MMU-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Mus musculus [BlackBoxEvent:R-MMU-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-975097
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[Reaction:R-MMU-975103] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
(inferredTo)	[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

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