Reactome | TPMT transfers methyl group to 6MP, forming 6MeMP

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TPMT transfers methyl group to 6MP, forming 6MeMP Show undefined attributes

catalystActivity	[CatalystActivity:10659727] thiopurine S-methyltransferase activity of TPMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10723675
displayName	TPMT transfers methyl group to 6MP, forming 6MeMP
eventOf	[Pathway:R-XTR-9748787] Azathioprine ADME - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
inferredFrom	[Reaction:R-HSA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Homo sapiens
input	[ChemicalDrug:R-ALL-9748998] 6MP [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TPMT transfers methyl group to 6MP, forming 6MeMP 6MP--TPMT-->6MeMP
output	[SimpleEntity:R-ALL-9748982] 6MeMP [cytosol] [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-XTR-9748996] GST dimers cleave AZA to 6MP - Xenopus tropicalis [Reaction:R-XTR-9751037] SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-XTR-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9748983
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9748787] Azathioprine ADME
(inferredTo)	[Reaction:R-HSA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP

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