p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter

Stable Identifier
R-HSA-9733207
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The heterotrimer composed of SMAD4 and two molecules of phosphorylated SMAD3 binds to the promoter of the collagen I gene COL1A2, together with the transcription factor SP1 (Zhang et al. 2000, Ihn et al. 2006) and the histone acetyltransferase EP300 (p300) (Higashii et al. 2003, Ihn et al. 2006). SMAD2 interferes with binding of SMAD3 to the COL1A2 promoter (Meng et al. 2010). The transcription factor YBX1, activated by interferon-gamma (IFNG) signaling can bind to SMAD3 at the COL1A2 promoter and interfere with the recruitment of EP300 (Higashi et al. 2003).
Literature References
PubMed ID Title Journal Year
11007770 Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription

Greenwel, P, Ou, J, Ramirez, F, Inagaki, Y, Zhang, W

J Biol Chem 2000
12917425 Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3

Higashi, K, Nakao, A, Nakatsuka, I, Kaneko, H, Inagaki, Y, Fujimori, K

J Biol Chem 2003
16319104 Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts

Tamaki, K, Yamane, K, Jinnin, M, Asano, Y, Ihn, H

Rheumatology (Oxford) 2006
20595680 Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis

Chung, AC, Huang, XR, Lan, HY, Shao, X, Ju, W, Qin, W, Bottinger, EP, Igarashi, P, Meng, XM

J Am Soc Nephrol 2010
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