Reactome | PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex

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PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex Show undefined attributes

authored	[InstanceEdit:9727487] May, Bruce, 2021-04-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9727501] May, Bruce, 2021-04-16
dbId	9727450
displayName	PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex
edited	[InstanceEdit:9727487] May, Bruce, 2021-04-15
eventOf	[Pathway:R-HSA-9845323] Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) - Homo sapiens
followingEvent	[Reaction:R-HSA-9845308] DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA - Homo sapiens
inferredFrom	[Reaction:R-MMU-9727502] Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex - Mus musculus
input	[Complex:R-HSA-9727479] BAF complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9909762] C19orf84 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212287] DNMT3A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5334123] DNMT3L [nucleoplasm] [DefinedSet:R-HSA-9844014] L1HS,L1PA2,L1PA3 RNA [nucleoplasm] [Complex:R-HSA-5601885] MeR-PIWIL4:2'-O-methyl-piRNA [nucleoplasm] [Complex:R-HSA-4657018] NuRD complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9727464] SPOCD1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9909708] C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
maxDepth	1
modified	[InstanceEdit:9910929] Matthews, Lisa, 2024-05-24
name	PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex
output	[Complex:R-HSA-9727438] nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5601897] MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9910930] Bourc'his, Deborah, 2024-05-24 [InstanceEdit:9910931] Fernandes, Liane P, 2024-05-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9727450
summation	[Summation:9731671] In fetal gonocytes undergoing de novo DNA methylation, piRNA...

Referrals

(hasEvent)	[Pathway:R-HSA-9845323] Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
(precedingEvent)	[Reaction:R-HSA-9845308] DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA
(inferredTo)	[Reaction:R-MMU-9727502] Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex

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