Reactome | DNMT3A [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9727438] nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] - Homo sapiens [Complex:R-HSA-5218928] Me2R4-HIST1H4:DNMT3A [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-4655440] CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 - Homo sapiens [Reaction:R-HSA-5212679] DNMT3A binds Me2sR4-HIST1H4 - Homo sapiens [Reaction:R-HSA-9727450] PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex - Homo sapiens
created	[InstanceEdit:212319] May, B, Gopinathrao, G, 2008-02-08 20:37:25
dbId	212287
displayName	DNMT3A [nucleoplasm]
endCoordinate	912
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-212287] DNMT3A [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-212287] DNMT3A [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-212287] DNMT3A [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-212287] DNMT3A [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-212287] DNMT3A [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-212287] dnmt3a [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-212287] DNMT3A [nucleoplasm] - Gallus gallus
maxDepth	1
memberOf	[DefinedSet:R-HSA-212315] DNMT1,3A,3B [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3132750] Wu, G, 2013-02-13
name	DNMT3A
referenceEntity	[ReferenceGeneProduct:uniprot:Q9Y6K1] UniProt:Q9Y6K1 DNMT3A
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-212287
startCoordinate	1

(input)	[Reaction:R-HSA-4655440] CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 [Reaction:R-HSA-9727450] PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex [Reaction:R-HSA-5212679] DNMT3A binds Me2sR4-HIST1H4
(hasComponent)	[Complex:R-HSA-9727438] nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] [Complex:R-HSA-5334143] DNMT3A:DNMT3L [nucleoplasm] [Complex:R-HSA-5218928] Me2R4-HIST1H4:DNMT3A [nucleoplasm]
(activeUnit)	[CatalystActivity:5334175] DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates of DNMT3A:DNMT3L:Chromatin [nucleoplasm]
(hasMember)	[DefinedSet:R-HSA-212315] DNMT1,3A,3B [nucleoplasm]
(requiredInputComponent)	[Reaction:R-HSA-9817458] TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3

DNMT3A [nucleoplasm] Show undefined attributes

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