Reactome | NuRD complex [nucleoplasm]

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NuRD complex [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9842855] NuRD:SUMO2-6K-TRIM28:KRAB-ZNF:retroelement chromatin [nucleoplasm] - Homo sapiens [Complex:R-HSA-8943778] SALL4:NuRD [nucleoplasm] - Homo sapiens [Complex:R-HSA-427352] TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] - Homo sapiens [Complex:R-HSA-9727438] nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes - Homo sapiens [Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes - Homo sapiens [Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes - Homo sapiens [Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes - Homo sapiens [Reaction:R-HSA-9842876] NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement - Homo sapiens [Reaction:R-HSA-8943780] SALL4 recruits NuRD to PTEN gene - Homo sapiens [Reaction:R-HSA-427404] Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene - Homo sapiens [Reaction:R-HSA-9976406] GATA3, CHD4, and the NuRD complex bind the TBX21 (T-BET) gene - Homo sapiens [Reaction:R-HSA-9727450] PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex - Homo sapiens
created	[InstanceEdit:4657017] Jupe, S, 2013-10-04
dbId	4657018
displayName	NuRD complex [nucleoplasm]
hasComponent	[CandidateSet:R-HSA-4657014] (GATAD2A, GATAD2B) [nucleoplasm] [Complex:R-HSA-4657004] HDAC1:HDAC2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4657010] MBD3 [nucleoplasm] [DefinedSet:R-HSA-4657021] Mi-2 [nucleoplasm] [DefinedSet:R-HSA-4657019] MTA1, MTA2, MTA3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212223] RBBP4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-212227] RBBP7 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-4657018] NuRD complex [nucleoplasm] - Mus musculus [Complex:R-RNO-4657018] NuRD complex [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-4657018] NuRD complex [nucleoplasm] - Canis familiaris [Complex:R-BTA-4657018] NuRD complex [nucleoplasm] - Bos taurus [Complex:R-SSC-4657018] NuRD complex [nucleoplasm] - Sus scrofa [Complex:R-DRE-4657018] NuRD complex [nucleoplasm] - Danio rerio [Complex:R-XTR-4657018] NuRD complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-4657018] NuRD complex [nucleoplasm] - Gallus gallus [Complex:R-DME-4657018] NuRD complex [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-4657018] NuRD complex [nucleoplasm] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:3730996] The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities [LiteratureReference:4657001] Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
maxDepth	3
memberOf	[DefinedSet:R-HSA-4657020] HDAC1:2-containing complex [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:6787649] Jupe, Steve, 2015-07-15
name	NuRD complex
negativelyRegulates	[NegativeRegulation:9844625] Negative regulation by 'NuRD complex [nucleoplasm]'
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-4657018
updateTrackers	[UpdateTracker:9889096] Update Tracker - [Complex:4657018] NuRD complex [nucleoplasm] - v48:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9889096] Update Tracker - [Complex:4657018] NuRD complex [nucleoplasm] - v48:[addLiteratureReference]
(input)	[Reaction:R-HSA-9727450] PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex [Reaction:R-HSA-9842876] NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement [Reaction:R-HSA-427404] Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene [Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes [Reaction:R-HSA-9976406] GATA3, CHD4, and the NuRD complex bind the TBX21 (T-BET) gene [Reaction:R-HSA-8943780] SALL4 recruits NuRD to PTEN gene
(hasComponent)	[Complex:R-HSA-9727438] nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] [Complex:R-HSA-9842855] NuRD:SUMO2-6K-TRIM28:KRAB-ZNF:retroelement chromatin [nucleoplasm] [Complex:R-HSA-427352] TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] [Complex:R-HSA-9844538] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] [Complex:R-HSA-9844534] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] [Complex:R-HSA-9844537] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] [Complex:R-HSA-9844535] NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] [Complex:R-HSA-9976373] GATA3:CHD4:NuRD:TBX21 gene [nucleoplasm] [Complex:R-HSA-8943778] SALL4:NuRD [nucleoplasm]
(activeUnit)	[NegativeGeneExpressionRegulation:9844551] Negative gene expression regulation by 'NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9844533] Negative gene expression regulation by 'NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm]' [NegativeRegulation:9844625] Negative regulation by 'NuRD complex [nucleoplasm]'
(regulator)	[NegativeRegulation:9844625] Negative regulation by 'NuRD complex [nucleoplasm]'
(hasMember)	[DefinedSet:R-HSA-4657020] HDAC1:2-containing complex [nucleoplasm]

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