Reactome | PGR binds PGR antagonists

PGR binds PGR antagonists

Stable Identifier

R-HSA-9726621

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The actions of progesterone, a critical regulator of normal female reproductive function in the uterus, the ovary, the mammary gland and the brain, are mediated via the progesterone receptor (PGR). The PGR antagonists mifepristone and ulipristal acetate are indicated for the medical abortion of pregnancy and as an emergency contraceptive, respectively. They both work by preventing the effects of progesterone on PGR (Zhi et al. 2003, Lusher et al. 2012, Rewinkel et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
12781197	Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators Schrader, WT, Tegley, CM, Risek, B, Marschke, KB, Edwards, JP, Zhi, L, Mais, DE, Jones, TK, Pio, B	Bioorg. Med. Chem. Lett.	2003
18243712	11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists Golstein, I, de Weys, D, Scholten, A, Hamersma, H, Wisse, J, Rewinkel, J, van Tilborg, M, van der Rijst, M, Enthoven, M	Bioorg. Med. Chem.	2008