Reactome | brigatinib-resistant ALK mutants don't bind brigatinib

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brigatinib-resistant ALK mutants don't bind brigatinib Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9715358] Rothfels, Karen, 2021-02-17
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9715356
disease	[Disease:1500689] cancer
displayName	brigatinib-resistant ALK mutants don't bind brigatinib
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
entityFunctionalStatus	[EntityFunctionalStatus:9714045] loss_of_function of brigatinib-resistant ALK mutants [plasma membrane]
eventOf	[Pathway:R-HSA-9717319] brigatinib-resistant ALK mutants - Homo sapiens
input	[ChemicalDrug:R-ALL-9699601] brigatinib [cytosol] [DefinedSet:R-HSA-9714046] brigatinib-resistant ALK mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9713857] A Compound L1196M/G1202R ALK Mutation in a Patient with ALK-Positive Lung Cancer with Acquired Resistance to Brigatinib Also Confers Primary Resistance to Lorlatinib [LiteratureReference:9713917] Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma [LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors [LiteratureReference:9715259] Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib [LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	brigatinib-resistant ALK mutants don't bind brigatinib
normalReaction	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9715356
summation	[Summation:9714031] The following ALK mutants show resistance to brigatinib: AL...

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[Pathway:R-HSA-9717319] brigatinib-resistant ALK mutants

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