Heme binds to four cysteine-proline motifs in the C-terminal region of BACH1 and inhibits the DNA-binding activity of BACH1-MAFK heterodimers resulting in HMOX1 induction. MAFK separates from the complex, and heme recruits nuclear exporters for BACH1 (Yoshida et al, 1988; Ogawa et al, 2001; Suzuki et al, 2004).
Yoshida, T, Biro, P, Cohen, T, Müller, RM, Shibahara, S
Ogawa, K, Sun, J, Taketani, S, Nakajima, O, Nishitani, C, Sassa, S, Hayashi, N, Yamamoto, M, Shibahara, S, Fujita, H, Igarashi, K
Suzuki, H, Tashiro, S, Hira, S, Sun, J, Yamazaki, C, Zenke, Y, Ikeda-Saito, M, Yoshida, M, Igarashi, K
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