Hemes bind to BACH1:MAFK

Stable Identifier
R-HSA-9707523
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Heme binds to four cysteine-proline motifs in the C-terminal region of BACH1 and inhibits the DNA-binding activity of BACH1-MAFK heterodimers resulting in HMOX1 induction. MAFK separates from the complex, and heme recruits nuclear exporters for BACH1 (Yoshida et al, 1988; Ogawa et al, 2001; Suzuki et al, 2004).

Literature References
PubMed ID Title Journal Year
3345742 Human heme oxygenase cDNA and induction of its mRNA by hemin

Yoshida, T, Biro, P, Cohen, T, Müller, RM, Shibahara, S

Eur J Biochem 1988
11387216 Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

Ogawa, K, Sun, J, Taketani, S, Nakajima, O, Nishitani, C, Sassa, S, Hayashi, N, Yamamoto, M, Shibahara, S, Fujita, H, Igarashi, K

EMBO J 2001
15175654 Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1

Suzuki, H, Tashiro, S, Hira, S, Sun, J, Yamazaki, C, Zenke, Y, Ikeda-Saito, M, Yoshida, M, Igarashi, K

EMBO J 2004
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