Heme binds to four cysteine-proline motifs in the C-terminal region of BACH1 and inhibits the DNA-binding activity of BACH1-MAFK heterodimers resulting in HMOX1 induction. MAFK separates from the complex, and heme recruits nuclear exporters for BACH1 (Yoshida et al, 1988; Ogawa et al, 2001; Suzuki et al, 2004).
Nishitani, C, Sassa, S, Nakajima, O, Taketani, S, Shibahara, S, Yamamoto, M, Hayashi, N, Igarashi, K, Sun, J, Fujita, H, Ogawa, K
Yoshida, T, Müller, RM, Biro, P, Shibahara, S, Cohen, T
Sun, J, Hira, S, Yamazaki, C, Yoshida, M, Igarashi, K, Ikeda-Saito, M, Suzuki, H, Zenke, Y, Tashiro, S
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