Reactome | Heme binds to four cysteine-proline motifs in the C-terminal...

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created	[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
dbId	9707520
displayName	Heme binds to four cysteine-proline motifs in the C-terminal...
literatureReference	[LiteratureReference:9707666] Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 [LiteratureReference:9707681] Human heme oxygenase cDNA and induction of its mRNA by hemin [LiteratureReference:9708432] Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1
modified	[InstanceEdit:9708426] Stephan, Ralf, 2020-11-30
schemaClass	Summation
text	Heme binds to four cysteine-proline motifs in the C-terminal region of BACH1 and inhibits the DNA-binding activity of BACH1-MAFK heterodimers resulting in HMOX1 induction. MAFK separates from the complex, and heme recruits nuclear exporters for BACH1 (Yoshida et al, 1988; Ogawa et al, 2001; Suzuki et al, 2004).

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