Reactome | Internalization of ubiquitinated FLT3

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Internalization of ubiquitinated FLT3 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:74700] endosome membrane
created	[InstanceEdit:9706366] Rothfels, Karen, 2020-11-04
dbId	9706364
displayName	Internalization of ubiquitinated FLT3
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9706369] Negative regulation of FLT3 - Homo sapiens
input	[Complex:R-HSA-9706245] Ub-pY FLT3:FLT3LG dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9706100] Flt3-dependent transformation by inactivating c-Cbl mutations in AML [LiteratureReference:9706063] CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Internalization of ubiquitinated FLT3
orthologousEvent	[BlackBoxEvent:R-XTR-9706364] Internalization of ubiquitinated FLT3 - Xenopus tropicalis [BlackBoxEvent:R-SSC-9706364] Internalization of ubiquitinated FLT3 - Sus scrofa [BlackBoxEvent:R-BTA-9706364] Internalization of ubiquitinated FLT3 - Bos taurus [BlackBoxEvent:R-CFA-9706364] Internalization of ubiquitinated FLT3 - Canis familiaris [BlackBoxEvent:R-MMU-9706364] Internalization of ubiquitinated FLT3 - Mus musculus
output	[Complex:R-HSA-9706242] Ub-pY FLT3:FLT3LG dimer [endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9706354] Ubiquitination of FLT3 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9706364
summation	[Summation:9706365] E3 ligase- mediated ubiquitination of FLT3 leads to its inte...

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[Pathway:R-HSA-9706369] Negative regulation of FLT3

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