Reactome | Ubiquitination of FLT3

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Ubiquitination of FLT3 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:9706357] ubiquitin protein ligase activity of FLT3 E3 ubiquitin ligases [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9706359] Rothfels, Karen, 2020-11-04
dbId	9706354
diseaseReaction	[FailedReaction:R-HSA-9706356] CBL mutants don't ubiquitinate FLT3 - Homo sapiens
displayName	Ubiquitination of FLT3
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9706369] Negative regulation of FLT3 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9706364] Internalization of ubiquitinated FLT3 - Homo sapiens
input	[Complex:R-HSA-9604751] Active FLT3 [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9706100] Flt3-dependent transformation by inactivating c-Cbl mutations in AML [LiteratureReference:9706063] CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes [LiteratureReference:9706144] Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling [LiteratureReference:9706148] Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3 [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Ubiquitination of FLT3
orthologousEvent	[BlackBoxEvent:R-XTR-9706354] Ubiquitination of FLT3 - Xenopus tropicalis [BlackBoxEvent:R-SSC-9706354] Ubiquitination of FLT3 - Sus scrofa [BlackBoxEvent:R-BTA-9706354] Ubiquitination of FLT3 - Bos taurus [BlackBoxEvent:R-CFA-9706354] Ubiquitination of FLT3 - Canis familiaris [BlackBoxEvent:R-MMU-9706354] Ubiquitination of FLT3 - Mus musculus
output	[Complex:R-HSA-9706245] Ub-pY FLT3:FLT3LG dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-9706350] FLT3 phosphorylates CBL - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9706354
summation	[Summation:9706358] FLT3 activity is negatively regulated by ubiquitin-mediated ...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9706356] CBL mutants don't ubiquitinate FLT3
(precedingEvent)	[BlackBoxEvent:R-HSA-9706364] Internalization of ubiquitinated FLT3
(hasEvent)	[Pathway:R-HSA-9706369] Negative regulation of FLT3