Internalization of ubiquitinated FLT3

Stable Identifier
R-HSA-9706364
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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E3 ligase- mediated ubiquitination of FLT3 leads to its internalization to the endosomal compartment (Sargin et al, 2007; Reindl et al, 2009; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
19276253 CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes

Reindl, C, Quentmeier, H, Petropoulos, K, Greif, PA, Benthaus, T, Argiropoulos, B, Mellert, G, Vempati, S, Duyster, J, Buske, C, Bohlander, SK, Humphries, KR, Hiddemann, W, Spiekermann, K

Clin Cancer Res 2009
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
17446348 Flt3-dependent transformation by inactivating c-Cbl mutations in AML

Sargin, B, Choudhary, C, Crosetto, N, Schmidt, MHH, Grundler, R, Rensinghoff, M, Thiessen, C, Tickenbrock, L, Schwäble, J, Brandts, C, August, B, Koschmieder, S, Bandi, SR, Duyster, J, Berdel, WE, Müller-Tidow, C, Dikic, I, Serve, H

Blood 2007
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