Reactome | Internalization of ubiquitinated FLT3

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:74700] endosome membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434746
displayName	Internalization of ubiquitinated FLT3
eventOf	[Pathway:R-BTA-9706369] Negative regulation of FLT3 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9706364] Internalization of ubiquitinated FLT3 - Homo sapiens
input	[Complex:R-BTA-9706245] Ub-pY FLT3:FLT3LG dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Internalization of ubiquitinated FLT3
output	[Complex:R-BTA-9706242] Ub-pY FLT3:FLT3LG dimer [endosome membrane]
precedingEvent	[BlackBoxEvent:R-BTA-9706354] Ubiquitination of FLT3 - Bos taurus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-9706364
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-9706369] Negative regulation of FLT3
(inferredTo)	[BlackBoxEvent:R-HSA-9706364] Internalization of ubiquitinated FLT3

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