SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed

Stable Identifier
R-HSA-9705726
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After binding CSF3 (G-CSF), the CSF3 receptor CSF3R is internalized into endosomes (Aarts et al. 2004). Only a minor portion of CSF3R is located at the plasma membrane. Most CSF3R is located internally in the Golgi, endosomes, and lysosomes (Aarts et al. 2004). Endocytosis depends on a dileucine motif in the C-terminal region of CSF3R (inferred from mouse homologs).

Literature References
Participants
Participates
Inferred From
Authored
Reviewed
Created
Cite Us!