SRD5A3 dehydrogenates TEST to DHTEST

Stable Identifier
R-HSA-9705714
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Testosterone is converted to 5-alpha-dihydroxytestosterone
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The conversion of testosterone (TEST) to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 3 (SRD5A3) (Uemura et al. 2008). SRD5A3 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).

Literature References
PubMed ID Title Journal Year
17986282 Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer

Uemura, M, Tamura, K, Chung, S, Honma, S, Okuyama, A, Nakamura, Y, Nakagawa, H

Cancer Sci 2008
9536209 A critical review of the origin and control of adrenal androgens

McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A3 [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
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