The conversion of testosterone (TEST) to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 3 (SRD5A3) (Uemura et al. 2008). SRD5A3 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).
Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK
Nakagawa, H, Tamura, K, Honma, S, Uemura, M, Chung, S, Okuyama, A, Nakamura, Y
3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A3 [endoplasmic reticulum membrane]
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