The conversion of testosterone (TEST) to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 3 (SRD5A3) (Uemura et al. 2008). SRD5A3 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).
Uemura, M, Tamura, K, Chung, S, Honma, S, Okuyama, A, Nakamura, Y, Nakagawa, H
McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK
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