Reactome | HDACs deacetylate p-STAT3 dimers

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HDACs deacetylate p-STAT3 dimers Show undefined attributes

catalystActivity	[CatalystActivity:10722807] protein lysine deacetylase activity of Histone deacetylase [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10722809
displayName	HDACs deacetylate p-STAT3 dimers
eventOf	[Pathway:R-XTR-9701898] STAT3 nuclear events downstream of ALK signaling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9701565] HDACs deacetylate p-STAT3 dimers - Homo sapiens
input	[Complex:R-XTR-9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	HDACs deacetylate p-STAT3 dimers
output	[SimpleEntity:R-ALL-427486] CH3COO- [nucleoplasm] [Complex:R-XTR-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm]
precedingEvent	[Reaction:R-XTR-9701531] p-Y705,S727 STAT3 is acetylated - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9701565
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9701898] STAT3 nuclear events downstream of ALK signaling
(inferredTo)	[Reaction:R-HSA-9701565] HDACs deacetylate p-STAT3 dimers

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