Active ALK binds FRS2

Stable Identifier
R-HSA-9700142
Type
Reaction
Species
Homo sapiens
Compartment
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The adaptor protein FRS2 binds activated ALK. Recruitment and activation of FRS2 does not depend on the juxtamembrane domain or any of the identified phosphotyrosine binding (PTB) NXXpY sites of ALK, and the binding site remains to be determined (Chikamori et al, 2007; Degoutin et al, 2007).

Literature References
PubMed ID Title Journal Year
17086210 Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation

Yamamoto, T, Tokai-Nishizumi, N, Fujimoto, J, Chikamori, M

Oncogene 2007
17274988 ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Vigny, M, Degoutin, J, Gouzi, JY

FEBS Lett. 2007
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