Reactome | ALK:MDK dimerization

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ALK:MDK dimerization Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9700139] Rothfels, Karen, 2020-09-14
dbId	9700137
displayName	ALK:MDK dimerization
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
inferredFrom	[Reaction:R-RNO-201531] ALK dimerization - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-201502] ALK [plasma membrane] [Complex:R-HSA-9667909] MDK:ALK [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition [LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer [LiteratureReference:201497] Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALK:MDK dimerization
output	[Complex:R-HSA-9699997] MDK:ALK dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-9667914] ALK binds ligand midkine (MDK) - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700137
summation	[Summation:9700138] Binding of MDK is believed to induce ALK receptor dimerizati...

Referrals

(hasEvent)	[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling
(precedingEvent)	[Reaction:R-HSA-201521] ALK autophosphorylation
(inferredTo)	[Reaction:R-RNO-201531] ALK dimerization

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