Reactome | ALK dimerization

Schema > Reaction > Entries

authored	[InstanceEdit:9729687] Rothfels, Karen, 2021-05-03
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
dbId	201531
displayName	ALK dimerization
edited	[InstanceEdit:9729687] Rothfels, Karen, 2021-05-03
input	[EntityWithAccessionedSequence:R-RNO-201543] Anaplastic lymphoma kinase [plasma membrane] [Complex:R-RNO-201529] PTN:ALK [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:201497] Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells [LiteratureReference:201494] Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin [LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALK dimerization
orthologousEvent	[Reaction:R-HSA-9700137] ALK:MDK dimerization - Homo sapiens [Reaction:R-HSA-201519] ALK:PTN dimerization - Homo sapiens
output	[Complex:R-RNO-201511] PTN:ALK dimer [plasma membrane]
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-201531
summation	[Summation:9702105] Studies with inducible dimerization constructs of rat ALK sh...