Reactome | ALK binds ligand midkine (MDK)

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ALK binds ligand midkine (MDK) Show undefined attributes

authored	[InstanceEdit:9667919] Orlic-Milacic, Marija, 2019-11-18
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9667901] Orlic-Milacic, Marija, 2019-11-18
dbId	9667914
displayName	ALK binds ligand midkine (MDK)
edited	[InstanceEdit:9667919] Orlic-Milacic, Marija, 2019-11-18
eventOf	[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9700137] ALK:MDK dimerization - Homo sapiens [Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-201502] ALK [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2160953] MDK [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ALK binds ligand midkine (MDK)
orthologousEvent	[Reaction:R-GGA-9667914] ALK binds ligand midkine (MDK) - Gallus gallus [Reaction:R-XTR-9667914] ALK binds ligand midkine (MDK) - Xenopus tropicalis [Reaction:R-DRE-9667914] ALK binds ligand midkine (MDK) - Danio rerio [Reaction:R-SSC-9667914] ALK binds ligand midkine (MDK) - Sus scrofa [Reaction:R-BTA-9667914] ALK binds ligand midkine (MDK) - Bos taurus [Reaction:R-CFA-9667914] ALK binds ligand midkine (MDK) - Canis familiaris [Reaction:R-RNO-9667914] ALK binds ligand midkine (MDK) - Rattus norvegicus [Reaction:R-MMU-9667914] ALK binds ligand midkine (MDK) - Mus musculus
output	[Complex:R-HSA-9667909] MDK:ALK [plasma membrane]
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9667914
summation	[Summation:9667903] ALK receptor tyrosine kinase binds to secreted growth factor...

Referrals

(hasEvent)	[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling
(precedingEvent)	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs [Reaction:R-HSA-9700137] ALK:MDK dimerization