Reactome | FLT3 D835del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9695757] FLT3 D835del dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9695711] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:9695692] COSMIC:COSV54042913
dbId	9695715
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 D835del [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentDeletionModification:9695639] Deletion of residues 835 to 835
inDisease	true
literatureReference	[LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
memberOf	[DefinedSet:R-HSA-9699523] tandutinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699530] sorafenib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane] - Homo sapiens
name	FLT3 D835del STK-1
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9695715
startCoordinate	27

(hasMember)	[DefinedSet:R-HSA-9699523] tandutinib-resistant FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699530] sorafenib-resistant FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699525] quizartinib-resistant FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9682396] kinase domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9695757] FLT3 D835del dimer [plasma membrane]